The Bijvoet Center houses advanced infrastructures for the analysis of proteins and other biomolecules using NMR, X-ray crystallography, electron microscopy and mass spectrometry and other technologies. Our high-resolution NMR spectroscopy instruments makes it possible to determine the structure of small to medium size proteins or other biomolecules. Combined with molecular dynamics, the functional interactions between biomolecules can be assessed. We use X-ray crystallography on in-house X-ray diffractometers and beam lines at the European Synchrotron in Grenoble to developed atomic resolution structures of proteins and protein complexes. Mass spectrometry is used for state-of-the art proteomics and for the structural characterization of biomolecules in relation to their biological function. Electron microscopy is used to analyze protein structures in a cellular context and light and super-resolution microscopy is employed to analyze proteins in living cells. Finally we use a wide variety of chemical and biochemical techniques in addition to structural studies to advance their understanding of the various functions of biomolecules and their interactions.
The Bijvoet Center is also one of the access Centres of the ESFRI project Instruct, a pan-European research infrastructure in structural biology, making high-end technologies and methods available to users. Together with other institutes in the Netherlands, the Bijvoet Center forms the Instruct-NL Centre. Through Instruct, European scientist from many countries, including the Netherlands, can get access to high-end structural biology technology throughout Europe.
The Bijvoet Center has a long history of providing access to their technologies and infrastructures to the Dutch, European and world-wide scientific communities. The pages below provide more information on the different infrastructures, the technologies available, and the possiblities for access to the instrumentation and expertise: