Chromatin & Transcription

Our research

RNA Polymerase II modelThe Chromatin & Transcription group is embedded in the Center for Regenerative Medicine at the Utrecht Science Park. The aim of the group is to train the next generation of biomedical scientists and medical doctors by performing internationally leading, fundamental biomedical research and by offering stimulating and excellent education. Research focuses on molecular processes in the cell, including signal transduction, mitosis, chromatin and gene regulation, by biochemical, genomic, proteomic, cell biological and systems biological approaches. Basic insight into these processes will provide vital insight into human disease such as cancer.

Our staff

Marc TimmersThe research focus of the Timmers lab of prof. dr. Marc Timmers is on molecular processes in the cell related to cancer and based on chromatin and gene regulation by biochemical, genomic, proteomic, cell biological and systems biology approaches. Their aim is to understand the molecular mechanisms of the interplay between chromatin modifications (in particular, histone methylation) and basal transcription factors like TFIID. Proper regulation of mRNA synthesis lies at the heart of cellular processes like cell proliferation and differentiation in eukaryotes. They employ and maintain “state-of-the-art” proteomics and genomics technologies to study the dynamics and genome localization of transcription factor complexes upon internal and external cues.